Cite Fiot E, Léger J, Martinerie L. Hormone Therapy During Infancy or Early Childhood for Patients with Hypogonadotropic Hypogonadism, Klinefelter or Turner Syndrome: Has the Time Come? Endocrinol Metab Clin North Am. 2024 Jun;53(2):307-320. doi: 10.1016/j.ecl.2024.02.003. Epub 2024 Mar 8. PMID: 38677872.
Abstract
Managing patients unable to produce sex steroids using gonadotropins to mimic minipuberty in hypogonadotropic hypogonadism, or sex steroids in patients with Klinefelter or Turner syndrome, is promising. There is a need to pursue research in this area, with large prospective cohorts and long-term data before these treatments can be routinely considered.
Keywords: Androgens; Estrogens; Gonadotropins; Hypogonadotropic hypogonadism; Klinefelter syndrome; Minipuberty; Turner syndrome.